"Neem Oil Poisoning as a Cause of Toxic Encephalopathy in an Infant"
"Poisoning is usually accidental by nasal or oral administered to infants and children for cough and cold, pain abdomen, and deworming; or rarely suicidal ... Even small doses can cause toxicity include vomiting, drowsiness, generalized seizures, coma, and severe metabolic acidosis especially in infants and young children ... Prognosis is usually good, however, delayed milestones, long term neurodeficits, recurrent seizures, abnormal ... (EEG), and deaths have been observed ... Since neem oil is commonly used as traditional medicine in India, its poisoning is not uncommon. ... pediatricians should be aware of this condition and public should be educated regarding the safe use of neem oil."
The bolding of text in all quotes is by me. The information speaks for itself. These are not studies. They are case reports. The information in this post is not new in that references of other case reports go back years!
"A rare case of toxic optic neuropathy secondary to consumption of neem oil", Full text
"Neem oil poisoning: Case report of an adult with toxic encephalopathy", Full text
"Herbal remedy is natural and safe"--truth or myth?"
"MARGOSA (NEEM) OIL POISONING"
http://www.pediatriconcall.com/Journal/Article/FullText.aspx?artid=485&type=J&tid=&imgid=&reportid=69&tbltype="The easy availability of margosa oil and its promotion without proper warning of these life threatening side effects warrant legislative measures and active awareness. This is a potentially toxic chemical and should be used with vigilance." Amen to that!
"Neem Oil Poisoning" - reference #6 in above link and heartbreaking!, Full text
"Exact toxicity level doses for humans are not known."
Natural Standard - neem oil uses - All grade C: "Unclear scientific evidence for this use" = UNPROVEN!